Non-Human Primate Animal Models for Human Deseases

Monkey Models for CNS Disorders
1. Depression
None invasive protocol of identifying depressed monkeys by behavioral criteria and biomarkers.
Natural models mimicking the etiology of human depression.

2. Parkinson's Disease (PD)
Chemically induced chronic PD model
Clinically similar to human PD patients in both the anatomical and the neurophysiologic deficits with highly predictive power.

Monkey Models for Metabolic Disorders
1. Liver Fibrosis
Alcohol induced chronic liver damage with clinically confirmed liver fibrosis in rhesus monkeys.

2. Type II Diabetes
High-fat food induced rhesus monkey Type II diabetic model.


Stem Cell Research and Resources

A world-leading research team in KBI on primate stem cell research, which has established multiple rhesus monkey embryo stem cell (ESC) lines, technology of nuclear transfer, protocol of non-invasive embryo transfer, and in vitro ESC differentiation and cell transplantation.


Primate Genomics Research and Personalized Medicine

An experienced research team in KBI on primate genomics studies, which has established a genome-wide rhesus monkey single nucleotide polymorphism (SNP) database, a valuable resource for animal genetic background profiling for drug test and animal reference for personalized medicine.


KBI Technology

Monkey Maze
Developed by KBI scientists, this is the first validated monkey maze in the world, providing a powerful tool for monkey behavior and cognitive studies, as well as for CNS drug screening and efficacy tests.

Monkey Transgenic Technology
As one of the rare research organizations in the world, KBI successfully grasped the technology of transgenic monkeys, the next-generation animal models using nonhuman primates.


Research Projects 

KBI is taking the primary leadership in conducting the national and provincial scientific research projects as follows:
 The project of “Development and Standardization of NHP model of Human Diseases” jointly supported by the Ministry of Science and Technology of China and Yunnan Provincial Government.
 The project of “International Identification and Authentication of Standardized Lab Animals of NHP” supported by Yunnan Provincial Science and Technology Department.
 The project of “The Establishment and Therapy of Rhesus Monkey Models for Diabetic Retinopathy and Age-related Macular Degeneration” supported by Yunnan Provincial Science and Technology Department.
 The project of “Key Technology Research in Establishment of Macaque Models for Chronic Parkinson's Disease” supported by Yunnan Provincial Development and Reform Commission.